Companion Diagnostics – Partnering for Personalized Medicine

September 15, 2010 · 3 comments

Industry Insights from Paul Meade, M. Sc, MPH

When the Human Genome Project was finally completed with the mapping of the genetic sequences of our DNA, there were many predictions about how the face of medicine would change forever. We would finally figure out how to cure diseases linked to genetic aberrations, find ways to enhance our interaction with the environment, and develop medicines that are tailored to fit our unique genome. But a decade later, we are all aware of just how painfully slow progress has been to date. However, one area that is advancing steadily is the use of companion diagnostics.

Everyone was quick to point to Herceptin and the prototype example of a diagnostic test that was required to be use prior to prescribing this chemotherapeutic agent for women with breast cancer that over-expressed the HER2/neu gene. But now there are more examples of such companion diagnostics, and the list continues to grow.

What does all this mean for the future of medicine, and the interaction among the diagnostic and biopharmaceutical companies? When we can go to a physician’s office, be correctly diagnosed, and then given a medicine to take knowing in advance that we will have a high probability of responding, without suffering from annoying side effects, then we will have personalized medicine.

Does that mean that people will have ... read more »

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Fast Facts from Thought Leader Select—Trends in HIV Reimbursement and Regulatory Involvement

September 14, 2010 · Leave a comment

Health care systems across the globe rely on the advice and counsel of health care professionals (HCPs) when making decisions on new therapies to approve appropriate levels of reimbursement for various pharmaceutical products. These regulatory and reimbursement advisers have various backgrounds, including health outcomes and economics, clinical pharmacy and medicine.

Within each medical discipline, certain physicians regularly advise government regulatory agencies and public and private insurers on which therapies meet unmet medical demands and have the lowest risk for adverse reactions as well as provide input into reimbursement considerations. Each key opinion leader (KOL) assessment conducted by Thought Leader Select includes an examination of KOL engagement in regulatory and reimbursement activities.

In an ongoing assessment of nearly more than 150 HIV key opinion leaders across the globe, Thought Leader Select has analyzed their participation in regulatory and reimbursement activities. Using keywords to link these KOLs with such activities, Thought Leader Select found that 33% of physicians regularly provide input into regulatory and reimbursement decisions. The 53 KOLs with regulatory and reimbursement involvement are split nearly in half according to their participation in general or HIV-related activities (see Chart 1). However, the majority of Thought Leaders studied are involved in public reimbursement efforts (see Chart 2). Common regulatory and reimbursement groups among studied ... read more »

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Rising Health Insurance – How to Win and Lose at the Same Time!

September 9, 2010 · Leave a comment

Industry Insights from Paul Meade, M. Sc, MPH

The front page of the Wall Street Journal announced yesterday that several health insurance companies are raising the premiums on their plans, which are likely to impact small businesses and individual policyholders. The reason cited for this unusually high hike in premiums is recent healthcare reform. The net result of all this it that the taxpayer pays for the added costs of healthcare reform, and the taxpayer pays for increased premiums that the insurance companies add as a result of healthcare reform.

This is like having car insurance, having an accident, and then watching your premiums quadruple for three years before returning to what they originally were before the accident. Guess who just paid for the accident? So why do we have insurance to protect us against an accident when ultimately we end up paying for the accident anyway?

Health insurance, like any insurance, is a risk game. Not for the insurance company, but for the consumer. If the insurance company lost enough money from insuring people, they would go out of business. So the game is simply this: take in more money than you pay out. If you pay out more than you expected in a given year, raise the premiums. If you pay out less than you thought you would, pocket the profits. ... read more »

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The Thought Leaders Driving Thought Leader Select: A Blog Series—Rhonda Napier

September 8, 2010 · 4 comments

Rhonda Napier joined Thought Leader Select as a research manager in the spring of 2010, after serving the company for two years as a researcher. A graduate of West Virginia University (bachelor’s degree in exercise physiology) and Marshall University (master’s degree in adult fitness and cardiac rehabilitation), Rhonda worked in research and clinical practice as an exercise physiologist for 13 years.

During her time at the Ohio State University College of Nursing, Napier led National Institutes of Health-funded research on the effects of exercise on hypertensive women. More recently, her work at the Gillings School for Global Public Health at the University of North Carolina at Chapel Hill focused on quality and access to healthcare.

The Thought Leader Select Blog
sat down with Rhonda to discuss her skills and experiences, as well as her contribution to the work of Thought Leader Select.

TLS Blog: Good afternoon, Rhonda. Why did you join Thought Leader Select?

Rhonda Napier:
I had the good fortune of meeting the company’s leadership team through my husband, Chris, after he became acquainted with them. That was back in 2008, and they had an opportunity for me to come into the company as a researcher. The idea of exclusively doing research for me was odd, because I had been a clinician for so many years—but I became ... read more »

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Medical Profession–Influence or Business as Usual?

September 2, 2010 · Leave a comment

Industry Insights from Paul Meade, M. Sc, MPH

As I wander down the aisle of my local grocery store, I pause at the various stations anchored the end of these long rows with people offering a “freebie” of some food product, a bite of sausage, some aged cheese, a new fruit drink. Each passerby stops briefly for his free sample and then moves along deciding whether to buy the product or not. When I arrive at the checkout, I casually hand over the collection of coupons I received in the mail to reduce my final bill. The reason I am at the store today is because of the flyer I received inside my weekly newspaper announcing a bevy of “specials.” Has the grocery store tried to influence my buying decisions? You bet they have. That’s good business.

Have you ever gone to buy a new car? Does the salesperson do everything within her ability to make the sale before you leave the showroom, offering you discounts, incentives, free service, and a favorable trade-in value for your old car? You bet she does! She knows that if you leave the showroom, the chances are you won’t be back–so she throws everything she can at you. Is she trying to influence your buying decision? Of course she is!

So then why is it, when a ... read more »

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Debunking Subjective Methods of Key Opinion Leader Identification

September 1, 2010 · Leave a comment

Recent conferences and literature on effective key opinion leader engagement show that identifying and engaging thought leaders is only getting tougher. Federal and state regulations of payments made to KOLs by pharmaceutical companies (Sunshine Act) and institutional restrictions of industry-related KOL activities reinforce the importance of identifying and engaging KOLs through objective means.

Older, subjective measures for selecting KOLs, such as prescribing habits or level of influence with other physicians, leave biopharmaceutical companies open to continued scrutiny and the possibility for legal action. These methods, like social network analysis (SNA), often lack the detail that industry decision-makers need to select the right KOLs for various types of engagement. Furthermore, it is also true that some objective means of identifying and selecting KOLs have their own limitations. Tracking conference involvement and publications alone is not enough to ensure you have found the top thought leaders in a given medical specialty.

Thought Leader Select has developed a methodology that uniquely provides biopharmaceutical decision-makers with the comfort that they’re identifying and selecting KOLs for the “right reasons”. Our “deep profiling” methodology tracks KOL activities across more than a dozen different areas and provides detailed participation data in a searchable framework that enables clients to select thought leaders in more sophisticated ways. Combining “deep profiling” with Thought Leader Select’s Professional Impact Network (PIN) enables decision makers ... read more »

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